What do Inflammation, Accelerated Aging and Cancer have in Common?

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Inflammation and DiseaseA key gene has been identified as being responsible for the control of inflammation and accelerated aging. Robert J. Schneider, PhD, principle investigator of the study, and the Albert Sabin Professor of Molecular Pathogenesis, associate director for translational research and co-director of the Breast Cancer Program at NYU Langone Medical Center, said “It is rather uncommon for one gene to have two very different and very significant functions that tie together control of aging and inflammation. The two, if not regulated properly, can eventually lead to cancer development. It’s an exciting scientific find.”

“The current study reveals that AUF1, a family of four related genes, not only controls the inflammatory response, but also maintains the integrity of chromosomes by activating the enzyme telomerase to repair the ends of chromosomes, thereby simultaneously reducing inflammation, preventing rapid aging and the development of cancer, Dr. Schneider explained.”

Dr. Schneider and his colleagues are doing further research to identify specific types of gene alterations in the AUF1 gene in humans which are associated with the co-development of particular immune diseases, as well as higher incidences of cancer and increased rates of aging, hoping to determine how the alterations develop and appear in clinically.

Infratonic Therapy has been proven to reduce inflammation; it may be worth investigating its ability to slow aging (some people swear it reduces their wrinkles). And using it in cancer treatment may sound like a stretch, but most great discoveries came from a stretch of the imagination, so maybe that will be the next study done…

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Journal Reference:

  1. Adam R. Pont, Navid Sadri, Susan J. Hsiao, Susan Smith, Robert J. Schneider. mRNA Decay Factor AUF1 Maintains Normal Aging, Telomere Maintenance, and Suppression of Senescence by Activation of Telomerase Transcription. Molecular Cell, 24 May 2012 DOI: 10.1016/j.molcel.2012.04.019

Photo Credit: nu-living.com

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